Posted by SLS on May 5, 2009, at 5:45:09
In reply to Why after increasing the dose? SLS-Anybody pls, posted by tepi on May 4, 2009, at 23:05:21
> This has happened me all the times during all the years I have been on med.
> It happened again today , Im on 45mg of Nardil
> increasing gradually to 60. I took for the first time the 60mg like this -
> 6 AM - 15mg
> 10 AM - 30 mg
> 3 PM - 15 mg
>
> I felt a very good effect on my fear to people after 2 hrs of taking 30 mg . I was very sociable and talking wiht selfconfindence.
>
> This has happened to me in the past. The problem is that this good effect only last during the first day. This happen wiht most of the drugs I have takne but I feel a better effect with Nardil
>
> What is this ? Im gonna have to make a plan to be decreasing - increasing the dose to have at leats some good days
>
> Anybody has any idea why this happen? I would do or give anythng to have this effect all the time.
> All my problems, All my life will be fixed feeling this way.
> TepiI do believe that you had a "blip" improvement that was acute to the dosage increases. I am certain that such things can happen biologically and it not need be a placebo effect. The pro-social effects of Nardil might come earlier than the antidepressant effects because of the way Nardil increases the activity of GABA neurons, which are calming. You don't need MAOI inhibition for this to occur. In addition, I used to experience an energy rush right after each dosage of Nardil. I think there is something pro-dopaminergic going on there, but I can't prove it.
My advice to you is to continue increasing the dosage of Nardil at a normal pace. There is no advantage for going backwards. Never, never, judge a drug as a failure if you feel better during the first week and have this improvement disappear. This improvement blip is sometimes an indicator that an antidepressant will ultimately prove therapeutic after the passage of time and making dosage adjustments. This is how the research clinicians at the NIMH interpret this blip phenomenon.
- Scott
poster:SLS
thread:894304
URL: http://www.dr-bob.org/babble/20090505/msgs/894323.html