Posted by bleauberry on May 1, 2009, at 16:57:30
In reply to Re: Opinions on Supplements with SAM-e, posted by uncouth on May 1, 2009, at 12:11:53
> really? I'm up to 175mg nortriptyline and I'm also taking 800mg of SAMe. i've only been on this combo for 2 weeks, but so far, i haven't noticed any bad interactions or serotonin syndrome.
>
> and I'm ALSO taking 120mg of Geodon, and 100mg of milnacipran a day, so i'm hitting serotonin from a bunch of different angles (and also taking some other junk, see my post below).
>You are hitting serotonin from different angles, but not at powerful levels. Nortriptyline is almost completely just norepinephrine, milnacipran is two thirds norepinephrine, and Geodon probably doesn't have any significant effect on increasing brain levels of serotonin. SAMe has been used in USA university clinical studies at very high doses incombination with high doses of Lexapro, and serotonin syndrome did not happen with anyone.
So I think you are safe from that concern.
That said, people have gotten serotonin syndrome from a single SSRI without any other drug involved, so risk is always present. That is rare though.
poster:bleauberry
thread:893719
URL: http://www.dr-bob.org/babble/20090426/msgs/893764.html