Posted by bleauberry on April 5, 2009, at 17:11:12
In reply to how much mg do i need to take of this?, posted by Jeroen on April 5, 2009, at 16:50:40
> how much mg do i need to take of this?
I actually don't know any more than what you and I have both seen in this thread. It might be possible to print up stuff on the topic, print stuff on the topic of seroquel and cortisol, and present what you find to the doctors. Then ask them to do a cortisol workup on you, preferably with at minimum a morning test and a night test, but better would be 4 tests througout a day. That help determine whether this approach should even be on the table or not.
The more straight forward thing I've mentioned a few times is to combine a tricyclic antidepressant with your seroquel. I would think either amitriptyline, nortriptyline, desipramine, or if you think you can handle the blurry eyes, dry mouth, and constipation stuff, go for the king clomipramine which has some 5ht2 action different than the others. I only mention these because of anecdotal stuff I've seen at pubmed and other places. No hard science. You've already been through all that. I just keep an eye out when I'm surfing for things that have worked for other people with treatment resistant psychosis or psychotic depression. The TCA+antipsychotic combo came up a few times.
Back to the cortisol thing, I know most of the benzos dampen down cortisol. I wonder if you've ever tried Klonopin or Lorazepam? Even though they are usually not thought of in terms of psychosis, my hunch is they could do some good. But if you've already tried them and had bad reactions, forget I said anything. :-)
poster:bleauberry
thread:888716
URL: http://www.dr-bob.org/babble/20090330/msgs/888852.html