Posted by bleauberry on April 5, 2009, at 6:18:47
In reply to Re: Jereon.....Check This Out » Phillipa, posted by yxibow on April 5, 2009, at 5:27:07
> > BB please don't confuse Jeroen. Thanks Phillipa
It's pretty straight forward and Jereon despite the illness seems to be intelligent.
>
> I don't know about confusing, but this is still under research even 9 years after this old article was published. There isn't clear large scale studies about cortisol and psychotic depression or other related disorders,
>
> -- Jay
>True enough. That can be said about any psychiatric disorder. No one can prove depression is low serotonin, and even if they could, they can't even measure it accurately without doing a spinal tap or a brain biopsy. Same with other disorders. They are all theories that are the best we have at this time, better than nothing, but cannot be replicated reliably over and over...which makes them non-facts.
Same with the meds. If one is to include the failed studies that were not presented to FDA for med approval, the so-called response rates would be considerably lower than they appear. Not to mention the cherry-picked patients when meds are studied. On and on. Don't get me going on that topic.
What I am saying is, it is made to sound like everything we deal with here in the psychiatry world is well studied and proven. None of it is. Sure, millions of hours and dollars are indeed spent, but the results are not much more clear now than 50 years ago.
All that said, Jereon has already valiantly patiently been through the best of the best that our science and studies shave to offer. Now being considered are weird "unproven" things like Memantine and other oddball approaches. One of them could be a miracle I have no doubt. But none are well studied, even years later, none are proven, and none are commonplace.
That's why when it comes to Jereon, I keep my eyes open for the other trees in the forest that we didn't see at first glance. When doing that, I see studies at pubmed where TCAs with antipsychotics worked on people with similar histories and Jereon. I stumble onto things like these observations concerning excess-cortisol, another one about seroquel lowering cortisol, and such, and start putting pieces of a theoretical puzzle together.
Jereon is way past anything that routine or protocol medicine has to offer. When things that are supposed to work don't, I think it is wise to reconsider the diagnosis, and reconsider other angles. The human body is so complicated that anyone who stays voluntarily within a confined pattern of thinking is limiting opportunity.
The observations presented were real. They happened. Doesn't matter if they are controversial, uncommon, or mysterious. They happened. They happened with enough robustness to surprise the clinicians in charge.
All I'm saying is Jereon won't get well on purer antipsychotics. Why? Been there, done that, all of them, combinations, even the gold standards. One at that point has to consider anecdotal cases, pioneering cases, and abstract cases as part of their armament against disease.
poster:bleauberry
thread:888716
URL: http://www.dr-bob.org/babble/20090330/msgs/888781.html