Posted by bleauberry on April 5, 2009, at 6:46:54
In reply to Re: cymbalta / effexor 5HT/NE reuptake ratios, posted by sowhysosad on April 4, 2009, at 19:13:38
> > I think you have reversed the ratios for 5HT:NE reuptake?
> >
> >
> > according to this article http://www.nature.com/npp/journal/v25/n6/abs/1395741a.html
> >
> > it appears that cymbalta is 1:9 serotonin:norepinephrine and effexor is 1:30...
>
> According to this one http://www.psychotropical.com/dual_action_ads.shtml it's 1:10 for cymbalta so pretty similar, but 1:200 for effexor!
>
> Maybe that would explain why a friend and my wife both suffered extreme agitation on effexor!
>Effexor has changing ratios as the dose changes...increased affinity for NE at higher doses. But no matter how you look at it, 1:30 or 1:200, yeah, it is basically a glorifed SSRI with not much effect on NE. I believe when they measure brain increases of NE and DA, Prozac actually does more of that than Effexor.
Exteme agitation. Yeah, that stinks. I don't know what causes that. Some would say that is a sign of bipolar. I think it could be any number of things. In any case, it basically tells me that whatever that med is, it is probably an offensive one for that person's particular biochemistry. Sometimes slow lengthened titration allows adaptation to be smoother so the agitation isn't severe and eventually is nonexistent. I've never had the strength to endure a med that felt that bad. My instincts just say..."poison!"
poster:bleauberry
thread:888069
URL: http://www.dr-bob.org/babble/20090330/msgs/888783.html