Posted by SLS on April 3, 2009, at 9:18:45
In reply to Re: To Scott, posted by Meltingpot on March 30, 2009, at 12:59:25
> Thanks for responding and the kind words. Re the Nortryptaline antagonising 5HT2A receptors, I've tried Mirtazapine in the past and didn't respond to it so wouldn't this rule out Nortryptaline?
They are two radically different drugs in the way they potentiate NE neurotransmission.
> If ECT worked I'd be prepared to do it once a month without a shadow of a doubt.
Yes. I would probably do it too.
> Zyprexa has always been a life saver for me, why do you think it helps so many people with suicidal thoughts?
It is sometimes overlooked that Zyprexa also binds to 5-HT2c receptors, which might increase DA and NE activity in the prefrontal cortex. Perhaps its antagonizing D4 receptors is also helpful.
> I dread to think what I'd do if it ever stopped helping me but I'd love to know what it does that helps.
I guess it would give clues as to how else to attack the depression.
> With your history of depression, what kept you going???
Death was illogical.
> Also, what does each drug that you are on give you in isolation?
- Parnate: Partial antidepressant response beginning on day 13 and ending by day 17.
- TCA: Complete remission antidepressant response beginning on day 13 and ending by the end of the third week.
- Lamictal: Typical early partial improvement at low dosages which disappears quickly. Stable partial improvement at 200mg.
- Abilify: A slight increase in mental energy and motivation.
> Do you have any theories on why medication poops out.
I really don't. Perhaps there is a disturbance in the system that allows for a change in second messenger cacades / gene function that serves to reduce the number of membrane-bound G-protein coupled 5-HT postsynaptic receptors. Over-downregulation.
> I'd love to know why the Seroxat stopped working after two years. Do you have a back up plan should the combination of drugs you are on stop working (God Forbid)?
No, not if it were to completely stop working. Add Topamax. Add Namenda.
I will be interested to see how people respond to agomelatine. Vilazodone might be an interesting drug for you if it ever becomes available. It is a 5-HT reuptake inhibitor and 5-HT1a partial agonist. It would be something like adding buspirone to paroxetine, only without the DA antagonism.> One other thing. A while back I brought up the subject of Deep Brain Stimulation for depression and I remember you saying that you had heard that there had been complications with Deep Brain Stimulation, can you elaborate?
I really don't recall having said that. I would wait for scientists to better locate the area(s) in the brain unique to each individual that produces the optimal focus of stimulation (which actually serves to interfere with neurotransmission).
- Scott
poster:SLS
thread:886950
URL: http://www.dr-bob.org/babble/20090330/msgs/888458.html