Posted by myco on March 8, 2009, at 19:43:36
In reply to Re: Inhibition of SULF1A3 = increase NARDIL bioavail? » myco, posted by Larry Hoover on March 8, 2009, at 19:31:22
Do you happen to know what enzymes use phenelzine as a substrate in the gut? I'm waiting to hear back from various psychiatric researchers about this but they are sooooo slow.
> > I can't find evidence either...this is my own personal research into how I, as a nardil user, may attempt to increase nardils bioavailability thus it's therapeutic effect. The idea was born out of reading this new study here:
> >
> > ""Inhibitory Effects of Herbal Extracts on the Activity of Human Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3)"
> >
> > Link: (http://www.jstage.jst.go.jp/article/bpb/32/1/105/_pdf)
> >
> > Can you offer any insight at all Larry? This is fascinating stuff.
> >
> > Thanks again,
> > Myco
> >
> >
> > > I can't find any evidence that phenelzine is a substrate of this enzyme. Do you have a reference for consideration?
> > >
> > > Lar
>
> What you suggest is theoretically possible. The substrates they mentioned, ritodrine and dopamine are similar enough in structure to phenelzine that it looks like it too might be a substrate. The list of foods and herbs that inhibit this enzyme is also quite extensive. I can't think of any reason why you shouldn't consider trying this, but just be very careful about interactions with the MAOI effect.
>
> Lar
poster:myco
thread:884466
URL: http://www.dr-bob.org/babble/20090304/msgs/884506.html