Posted by Larry Hoover on March 8, 2009, at 19:31:22
In reply to Re: Inhibition of SULF1A3 = increase NARDIL bioavail? » Larry Hoover, posted by myco on March 8, 2009, at 17:35:33
> I can't find evidence either...this is my own personal research into how I, as a nardil user, may attempt to increase nardils bioavailability thus it's therapeutic effect. The idea was born out of reading this new study here:
>
> ""Inhibitory Effects of Herbal Extracts on the Activity of Human Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3)"
>
> Link: (http://www.jstage.jst.go.jp/article/bpb/32/1/105/_pdf)
>
> Can you offer any insight at all Larry? This is fascinating stuff.
>
> Thanks again,
> Myco
>
>
> > I can't find any evidence that phenelzine is a substrate of this enzyme. Do you have a reference for consideration?
> >
> > LarWhat you suggest is theoretically possible. The substrates they mentioned, ritodrine and dopamine are similar enough in structure to phenelzine that it looks like it too might be a substrate. The list of foods and herbs that inhibit this enzyme is also quite extensive. I can't think of any reason why you shouldn't consider trying this, but just be very careful about interactions with the MAOI effect.
Lar
poster:Larry Hoover
thread:884466
URL: http://www.dr-bob.org/babble/20090304/msgs/884501.html