Posted by SLS on February 28, 2009, at 15:08:23
In reply to Very, very worried, need advice and some hope, posted by meltingpot on February 28, 2009, at 14:11:55
Hi Denise.
Is this your first tricyclic?
Your type of depression is called endogenous or melancholic. It is often more responsive to tricyclics than SSRIs. Years ago, clomipramine was considered to be the best of the bunch with regard to the statistical response rate. It is particularly good when treating OCD. In some ways, Seroxat and clomipramine are similar in that they both inhibit the reuptake of serotonin and norepinephrine. However, clomipramine is more potent with norepinephrine. Clomipramine might be thought of as a stronger Seroxat.
If clomipramine doesn't work by itself, there are things that can be added to it. However, you cannot combine an MAOI with clomipramine as you can with desipramine or nortriptyine.
How are you doing with side effects so far? With clomipramine, you are going to get anticholinergic side effects, but these can become less troublesome as treatment progresses. It should be stated, though, that some believe the anticholinergic properties actually enhance the antidepressant potency of a drug.
At what rate do you intend to increase the dosage?
- Scott
poster:SLS
thread:883081
URL: http://www.dr-bob.org/babble/20090223/msgs/883084.html