Posted by garnet71 on February 24, 2009, at 12:39:09
In reply to 40mg, 10mg q.i.d. vs. 20mg, 5mg q.i.d of buspirone, posted by iforgotmypassword on February 23, 2009, at 14:50:42
http://www.mentalhealth.com/drug/p30-b03.html
Possible Concerns Related to Buspirone's Binding to Dopamine Receptors:
Because buspirone can bind to central dopamine receptors, a question has been raised about its potential to cause acute and chronic changes in dopamine mediated neurological function (e.g., dystonia, pseudoparkinsonism, akathisia, and tardive dyskinesia). Clinical experience in controlled trials has failed to identify any significant neuroleptic-like activity; however, a syndrome of restlessness, appearing shortly after initiation of treatment, has been reported in some small fraction of buspirone treated patients. The syndrome may be explained in several ways. For example, buspirone may increase central noradrenergic activity; alternatively, the effect may be attributable to dopaminergic effects (i.e., represent akathisia). Obviously, the question cannot be totally resolved at this point in time. Generally, long-term sequelae of any drug's use can be identified only after several years of marketing.
Effects on Cognitive and Motor Performance:
...The effect of higher single doses of buspirone on psychomotor performance has not been investigated.---------------------
I'm confused again. Meds for anxiety really suck.
poster:garnet71
thread:881941
URL: http://www.dr-bob.org/babble/20090223/msgs/882176.html