Posted by iforgotmypassword on February 23, 2009, at 14:50:42
I am trying to avoid "neuroleptic" doses of buspirone. I have heard on this forum something to the effect of "anything over 30mg and neuroleptic effects start to set in," "anything over 30mg is not ideal/not tolerable." These are not exact quotes but my approximations of the variations on this i have read. Both common "neuroleptic" effects and tardive extrapyramidal symptom risk worry me greatly.
My plan is to move to q.i.d. (4x a day divided dosing) for taking my buspirone. I am wondering if this will help avoid any neuroleptic effect by keeping maximum D2 occupancy lower (but more stable and flat, less peaky, at a lower occupancy level.) Also however, I am wondering if this will divide the effective dose too thin, does the 5-HT1A effect need to be "peaky" in order to work?
I am hoping the fact that a company was at one point looking at marketing a buspirone patch may be an indication that it can work. Then again, the buspirone patch didn't seem to materialize. It seems there could be any reason why, even further ineffectiveness, or the simple difficuly in marketing transdermal patches... I don't know, did anyone follow this?
Above 30mg in total daily dose, I am leaning towards 40mg divided as 10mg q.i.d. (over 20mg divided as 5mg q.i.d.) but I may have faulty reasoning; I know buspirone has more than just the 1-PP active metabolite, so maybe it is more cumulative and divided dosing not as useful. Only 10mg pills seem to be available here, and are scored only once, and are only about the size to be split once anyway. So the doses seem to be set at 5mg or 10mg or an irregular combination of the two (but I always feel wierd about doing things like that.)
To clarify, as before, I am both trying to avoid adverse antidopaminergic effect due to my current extrapyramidal problems that have been permanent and the major dysexecutive, apathetic, anhedionic, avolitional, and amotivation problems I have, which are central and along with the cognitive are the most disabling of my difficulties. Also my problems with unreliable and unstable energy levels do not need to get any worse.
I hope this was not too long. My main questions were in my second paragraph.
Thank you very much for any input and, I hope today is a good day for as many people here as possible.
poster:iforgotmypassword
thread:881941
URL: http://www.dr-bob.org/babble/20090223/msgs/881941.html