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Re: Memantine vs Amantadine (what difference?) » psychobot5000

Posted by SLS on February 2, 2009, at 21:27:27

In reply to Memantine vs Amantadine (what difference?), posted by psychobot5000 on February 2, 2009, at 21:09:48

> Hi,
>
> I've been researching memantine (for anxiety, OCD, depression), and found that it seems to be very close to amantadine in most respects. Does anyone know why memantine is being researched and considered for these indications and not its sister drug? Why does memantine get all the attention?


I am not sure of all the reasons. Memantine is a cleaner drug if your are looking for NMDA antagonism. It is also a significantly more potent ligand. It binds to the receptor with greater affinity. Amantadine produces side effects, including psychiatric side effects, that make it less than desirable.


- Scott

 

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