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Re: Epigenetics and mental illness

Posted by Larry Hoover on January 19, 2009, at 14:13:29

In reply to Epigenetics and mental illness, posted by Larry Hoover on January 17, 2009, at 20:19:46

This was just published yesterday. I have never ever seen such a small P value.

Lar

Nature Genetics
Published online: 18 January 2009 | doi:10.1038/ng.286


DNA methylation profiles in monozygotic and dizygotic twins
Zachary A Kaminsky1,2, Thomas Tang1, Sun-Chong Wang1,3, Carolyn Ptak1,2, Gabriel H T Oh1,2, Albert H C Wong1,2, Laura A Feldcamp1,2, Carl Virtanen4, Jonas Halfvarson5,6, Curt Tysk5,6, Allan F McRae7, Peter M Visscher7, Grant W Montgomery7, Irving I Gottesman8, Nicholas G Martin7 & Art Petronis1,2


Top of pageTwin studies have provided the basis for genetic and epidemiological studies in human complex traits1, 2. As epigenetic factors can contribute to phenotypic outcomes, we conducted a DNA methylation analysis in white blood cells (WBC), buccal epithelial cells and gut biopsies of 114 monozygotic (MZ) twins as well as WBC and buccal epithelial cells of 80 dizygotic (DZ) twins using 12K CpG island microarrays3, 4. Here we provide the first annotation of epigenetic metastability of 6,000 unique genomic regions in MZ twins. An intraclass correlation (ICC)-based comparison of matched MZ and DZ twins showed significantly higher epigenetic difference in buccal cells of DZ co-twins (P = 1.2 x 10^-294). Although such higher epigenetic discordance in DZ twins can result from DNA sequence differences, our in silico SNP analyses and animal studies favor the hypothesis that it is due to epigenomic differences in the zygotes, suggesting that molecular mechanisms of heritability may not be limited to DNA sequence differences.

 

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poster:Larry Hoover thread:874594
URL: http://www.dr-bob.org/babble/20090104/msgs/874974.html