Posted by Sigismund on January 8, 2009, at 19:56:20
In reply to Re: BUPRENORPHINE, posted by sunkistcat79 on January 8, 2009, at 17:10:51
I have never taken bupe, but I am familiar with methadone, morphine and the rest.
>Think about this. The first time I ever took an opioid, I took it for about 2 weeks and, like everyone else, I always needed to increase my dose, but this experience never changed: 30 minutes after taking my dose (prescribed for pain), I felt sleepy/high-ish. This wore off in about 45 mins. and left me clearer, happier, calmer, and leveler than I HAVE ANY RECOLLECTION OF.Well, yes. I know exactly what you mean.
>Doesn't it make sense that upon taking the opioid, there was a relatively high amount of the chemical in my system (a system that had been very devoid of endorphins) and it went into overload (hence- feeling high). Most people feel high for hours, but this wore off for me because soon, the chemical leveled out and instead of having an above-average amount in my system, now I just have an average amount.You may be right. I don't know
>But my guess is this, FWIW.
Whenever an opioid is taken in such a way that plasma levels are even, tolerance becomes almost total.
With bupe there is a kappa opioid antagonism (?) which I don't understand.The link undopaminergic put up about methadone withdrawal is certainly stunning if true. It will be in my post below this.
poster:Sigismund
thread:872613
URL: http://www.dr-bob.org/babble/20090104/msgs/872832.html