Posted by linkadge on November 2, 2008, at 15:19:22
In reply to Re: Its not going to be used for alzheimers, posted by JadeKelly on November 2, 2008, at 14:22:25
Question: If Alzheimer's is in the early stages, isn't it conceivable that the Depakote could still have benefit on plaque formation? Or are you saying its too late then.
Its possible, but without human studies the net effect is really uncertain. Valproate has so many effects. Ion channel inihibition tends to dull the intelect as does its gabaergic effect. It is also a HDAC inhibiitor which can affect neuronal placticity in certain ways.
>Do you know of any?
Yes the omega-3 fatty acid DHA inhibits GSK-3b quite well and does the exact same thing for plaques in mice. You can look up alzheimers + DHA in google. And, the beneifit is that DHA has cognative enhancing effects even in mice without alzheimers. DHA has no ion channel blockade like valproate. The problem is that greedy drug companies want a chemical they can patent to administer to patients, when safer agents with superior activity are already available.
Linkadge
poster:linkadge
thread:859623
URL: http://www.dr-bob.org/babble/20081027/msgs/860432.html