Posted by JadeKelly on November 2, 2008, at 14:22:25
In reply to Re: Its not going to be used for alzheimers, posted by linkadge on November 2, 2008, at 9:43:18
> Folks, the point of this study was really not to suggest that valproate itself is going to treat Alzheimers.
Understand.
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> Valproate is *NOT* currently used to treat Alzheimers. If it is used in Alzheimer's patients it is used for its sedative and/or mood stabilizing effects. I.E. it is just being used to control behavioral symptoms associated with Alheimer's or dementia.
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> Seroquel is also *NOT* used to treat Alzhimers. Studies show that atypicals speed the progression of cognative decline in Alzheimers. If it is being used, it is used for behavioral control and/or emotional symtpoms that are associated with the disease.Its a real shame that the disease causes behaviors that then require treatment with drugs that impair memory and cognitive ability in the short AND long term.
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> The study that was done was in mice. Keep in the mind that study only showed that valproate reduced the formaiton of plaques and tangles associated with the disease. There is no evidence that it can actually do anything for the disease after the plaques have formed. And also, as mentioned, the drug has nasty cognitive side effects of its own which may totally outstrip any Alzheimers preventitive effect.
Question: If Alzheimer's is in the early stages, isn't it conceivable that the Depakote could still have benefit on plaque formation? Or are you saying its too late then.
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> The real point of the study was to suggest that researchers can look for other, more selective GSK-3b inhibitors to do the same thing in a more palatable way.Do you know of any?
Thanks for all the info. It helps.
Jade
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> Linkadge
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poster:JadeKelly
thread:859623
URL: http://www.dr-bob.org/babble/20081027/msgs/860417.html