Posted by Extreme on October 25, 2008, at 7:16:06
In reply to Re: confusing nomenclature » Extreme, posted by lucie lu on October 24, 2008, at 18:30:14
> Histamine has a few different roles in the body. As you say, it can be involved in allergy but not in the brain since the antibodies (which help produce the true allergic response) are too big to cross the blood-brain barrier. But histidine (the free form, not the form making up proteins) can be made into histamine which is small enough to pass freely across the blood brain barrier. The action of histamine in this context is as a neurotransmitter, and could still (I guess) be involved in your particular reaction to certain drugs. Have you tried posting this on the neurotransmitter board?
My original post was there. This is intersting... I think I have even read about histamines role as a neurotransmitter somewhere before... supposed to be part of regulating sleepiness or something like that? I too figured that histamine in the context of allergy would be somewhat different to the histamine in the brain... but then I never knew that the antibodies responsible for allergy cannot pass the blood brain barrier. I think I looked into these things many years back considering if my blood brain barrier actually was failing and letting things up there that should not be there. But then maybe a "simple" overproduction of histidine would explain increased histamine-levels in the brain somehow during allergy.
>These folded molecules can sometimes change the way they are folded but not their amino acid sequence, at least not in the way you mean. Did you have something particular in mind?
Just wondered if they show some "creative" properties but I can see now that it is more likely that whatever happens in my brain has something to do with a substance attaching/being added to the gaba-receptor making it difficult for benso to attach to it. I have never looked into to it but during allergy season when benso was inactive indeed one more substance with links to gaba-systems was also completly inactive... kava kava. I can only come to the conclusion that kava like benso had trouble attaching to the gaba-system because some other substance was already in place blocking them from it.
I'll round up here so I dont get caught in "verbal overshadowing".
> You should go into research, you have a healthy curiosity and a questioning mind :)
Well, thank you Lucie!!! Something has to be healthy in me I suppose :P
I really appreciate that you share your knowledge!!
poster:Extreme
thread:858937
URL: http://www.dr-bob.org/babble/20081016/msgs/859222.html