Posted by lucie lu on October 24, 2008, at 18:40:03
In reply to Re: confusing nomenclature, posted by Extreme on October 24, 2008, at 5:55:42
> Another question Lucie ;)
>
> Does the "histamine-turnover-effect" caused by large doses of nitrazepam in rats brain (as stated on wiki on nitra) imply that histamine is a standard part and active part of the same polypetide-chain in the gaba-a receptor as histidine? Or is it simply taken out of context and refers to histamine in another part of the systems...I looked at the Wikipedia article you cited. I think what they are referring to is something called "down-regulation" which is the body's way of decreasing sensitivity to a substance (e.g. drug or hormone) when dosages are high. So I think you are right in that it is a different context. Histamine, although it is an amino acid, is not one of the 20 that makes up protein sequences.
Hope this isn't too confusing. These topics certainly can be fascinating to explore!
Lucie
poster:lucie lu
thread:858937
URL: http://www.dr-bob.org/babble/20081016/msgs/859138.html