Posted by Marty on October 23, 2008, at 19:33:33
In reply to Re: Beauty and sadness, posted by linkadge on October 23, 2008, at 16:40:28
Link,
There's something interesting in this discussion ONLY if your response is worst on Prozac than on the other (more typical) SSRIs. Is it the case or not ?
If you already answered me about it when I asked the other times than I'm sorry; I've missed it.
You said: " Thats like saying that because aspirin doesn't kill childbirth pain that there is something wrong with the way a mother's inflammation system is repsonding to the aspirin."
It's not. What I'm saying is more like if aspirin induce migraine each time Joe the plumber is taking one then Joe may have something biologically different that's causing this atypical response... something different from the people who benefit from the typical response.
IF you feel way worst on Prozac than on other SSRIs, it COULD be because of the 5-HT2c antagonistic properties of Prozac since it's about the only -relevant- difference between Prozac and others. It matters because 5-HT2c antagonism very typically makes people feels better.. and so, while it doesn't tell you more about the precise etiology of your disorder, it gives you the opportunity to tweak something that may end up improving your condition.
Things I would think about/try based on this atypical response to 5-HT2c antagonism:
1. More/different 5-HT2c antagonism with no SRI action: Agomelatine (already out there) or low dose Geodon (pre-DA antagonistic dose = 5-HT2c antagonism)2. Light (Not LSD strong) 5-HT2c agonism: low dose mCPP could do the trick. One of Trazodone metabolite happen to be mCPP. SRIs properties of Trazo is pretty weak and it's 5-HT2a antagonistic properties are good for emotions. To see how 5-HT2c agonism makes you feel only 1 or 2 days of Trazo would be enough to see.. you take it before bed and a couple hours after you wake up you'll feel it. No need for clinically active dose.
Anyway... Wish you well,
/\/\arty
poster:Marty
thread:857746
URL: http://www.dr-bob.org/babble/20081016/msgs/859011.html