Posted by linkadge on October 23, 2008, at 16:40:28
In reply to Re: Beauty and sadness » linkadge, posted by Marty on October 23, 2008, at 12:40:26
>It doesn't work that way in normal peoples brain >or maybe even "normal depressive/responder" >people, but in non-responder or atypical >responder there's something that may doesn't >work the same 'normal' way .. so those >homeostatis/adaptation mechanism may be out of >balance.. that's the whole point Linkadge.
Un, not ncessarily. The receptor adaption hypothesis is just a hypothesis (and a very old and weak on IMHO).
Just because an SSRI isn't working doesn't necessarily mean the receptors are not downregulating/upregulating. It could also mean you are messing with a particular brain system which is not even involved in your disease. I.e. if your disorder involves endorphin, gaba, PEA, dopamine, norepinephrine, substance P, galanin, oxytocin, vasopressin, NGF, BDNF, histamine, or any one of the other dozens of brain chemicals that might be implicated in depression then of course your brain is not going to respond to an SSRI like other patients.
So it doesn't really make sense in my mind to suggest that because somebody doesn't respond to an SSRI then there brain is not respondiing "as it should". Thats like saying that because aspirin doesn't kill childbirth pain that there is something wrong with the way a mother's inflamation system is repsonding to the aspirin.
Linkadge
I've been on all the SSRI's a million times. I don't know why I let a doctor convince me into trying a worthless (for me) drug again.
poster:linkadge
thread:857746
URL: http://www.dr-bob.org/babble/20081016/msgs/858990.html