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SSRIs, REM sleep and memory

Posted by NKP on October 19, 2008, at 12:17:23

Apparently SSRIs reduce REM sleep by between 30-50% (and therefore increase non-REM sleep). REM sleep is involved in consolidating procedural and spatial memory. Non-REM sleep is involved in consolidating declarative memory.

Paradoxically, SSRIs appear to have no adverse effect on procedural or spatial memory, whereas in the case of setraline at least (possibly other SSRIs too), declarative memory appears to show improvement.

Your thoughts please.


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