Posted by kingcolon on September 22, 2008, at 11:17:00
In reply to Re: Buprenorphine experiences, posted by okydoky on September 22, 2008, at 8:39:51
You clearly need to take the Sub with a frequent dosing interval for pain relief. Anyone who's been using opioids chronically before starting Sub should find a dose that alleviates any withdrawal symptoms (eg, anxiety) before adjusting the dose further for pain or depression. This can be quite high (8 mg daily and higher) for some. However, most can cut back and get good control of both relapse and pain/depression with 8 mg or less. I've heard that some opioid addicts believe that "more is less" with this drug, in the long run, and that finding the minimum dose that helps is a good idea. For depression, I doubt that higher doses correlate with increased efficacy. I put Sub under the tongue in front and sort of clamp my tongue down on it while keeping my saliva "away" from there, holding it elsewhere in the mouth. I do this until the pill completely dissolves under the tongue which you can tell by moving your tongue over it and not feeling grittiness. This takes about 10 min for me, and sometimes I keep the remaining saliva in for a while longer, swishing it around.
As for Sub vs. oxy/MS, the fact that Sub has been effective even for ECT resistant depression suggests to me that it is at least as effective as the pure agonists for depression. Someone mentioned before that it has kappa antagonism, which oxy/MS doesn't, and this adds to it's antidepressant effects. What it isn't is a drug that makes you feel good because you're high on it(ie euphoric). (If you're dysthymic or dysphoric you will feel euthymic--in other words, "normal") Hope this helps a little.
KC> Thanks for the input. Like every other narcotic I have taken it never lasts as long as the script says. Ive been taking 6-8mg day. Was supposed to be in two doses but I take 3mg and then at some point have breakthrough pain ( usually about 7 hours into the days first dose) and take 1 or 2 mg and then at 12 hours take 2 or 3mg for my last dose. I have been taking the naproxen with it to because the first day when i took 4mg my breathing was depressed so I thought I could not take enough for the pain. I will know more soon hopefully. I don't have a set amount yet because of the flare. Yesterday I had to take so much Lyrica I had no need for the second dose of Sub but I took it anyway. Can I ask exactly where you place the tab under your lip so that it dissolves the best and i don't end up swallowing some of it? It has been three days and the rawness is starting to where off. Not sure if it was withdrawal or what? I am definitely more anxious though. I have a definite need to take a tranquilizer. I have Klonopin and perphenazine at hand. completely or at least it seems so. Does anyone have an opinion as to whether Sub would be a better antidepressant than oxycontin or morphine or any of the opiates? I have more questions but I have to get my dog to the vet.
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> Thanks and talk later,
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> Oky
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> p.s. as soon as my need for Lyrica is gone I will start on Amineptine I think.
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poster:kingcolon
thread:831927
URL: http://www.dr-bob.org/babble/20080915/msgs/853401.html