Posted by bleauberry on September 4, 2008, at 20:26:07
In reply to Re: SLS and all....5ht1a autoreceptor antagonists...., posted by SLS on September 4, 2008, at 18:56:53
SLS,Thanks, very helpful stuff.
You asked what I'm on. Nothing. But definitely need something. Doc wants me back on doxycycline as he suspects nervous system inflammation, unknown micro-organism infection, and my one day miracle response to it after feeling bad on it for 2 weeks. A common side effect of doxy in normal people is depression or mood swings, but there are reports of treatment resistant depression responding robustly to it. It is anti-inflammatory, antibacterial, and it somehow turns on the genes that instruct the 5ht1a autoreceptors to not be excessively sensitive. Weird, they are linking crib death to a genetic 5ht1a malfunction where it is to sensitive, resulting in lack of serotonin, and the resutling negative downstream effects on body temp, breathing, and heart function.Hey, pindolol looks perfect for me...theoretically that is. I've told docs many times it feels like when I start a reuptake inhibitor I feel improvement immediately, but within four days it feels like everything just shuts down and then I get worse and worse real fast. It's like I need the serotonin, it feels good, but as soon as the autoreceptors figure out what is going on, they say "no way", and turn everything off. That is exactly what it feels like and I've been through it so many times. Pindolol might prevent that, and in addition, the ne beta antagonism might improve the urinary muscle constrictions of milnacipran, which by a longshot has been my biggest promise in recent years.
I do not understand what an agonist would do. Would that further worsen an already over-sensitive receptor?
Also could you please explain to me what a "reverse agonist" is and how it works? When I see that term it confuses me.
Anyway, not sure where to go. I see a psych RN who is really good in 2 weeks. While her partner doctor is handling my physical stuff, he wants her to take over the mood stuff. Looks like Doxy is a definite, but I believe I will need more than that. The RN knows I respond fast to Ritalin and she is quite liberal with the pen, so she might just treat me symptomatically as I go through other physical treatments. No idea. My choice would be to endure the excruciation of Doxy for a couple weeks, see where it goes, and then decide. In the meantime I am fairly convinced my biggest help with me in receptor manipulation rather than neurotransmitter levels, so I am learning as much as I can to gear up for that attack. That's a new angle for me.
Thanks again for your help!
> 1. pindolol - 5-HT1a somatodendritic autoreceptor antagonist; NE beta 1 receptor antagonist
>
>
> > I don't know about 5ht1a agonists or partial agonists, but if you do, please share. Anything that will wake up the receptors and keep them from oversensing too much serotonin when in fact there isn't enough.
>
>
> 1. buspirone - 5-HT1a postsynaptic partial agonist; 5-HT1a autoreceptor full agonist; D2 receptor antagonist; NE alpha2 receptor antagonist (1-PP metabolite)
>
> 2. gepirone - 5-HT1a postsynaptic partial agonist; 5-HT1a autoreceptor full agonist; NE alpha2 receptor antagonist (1-PP metabolite)
>
> 3. ipsapirone - 5-HT1a postsynaptic partial agonist; 5-HT1a autoreceptor full agonist; NE alpha2 receptor antagonist (1-PP metabolite)
>
> 4. flexinoxan - 5-HT1a postsynaptic partial agonist; 5-HT1a autoreceptor full agonist
>
>
> * Repeated administration of milnacipran induces rapid desensitization of somatodendritic 5-HT1A autoreceptors but not postsynaptic 5-HT1A receptors
>
>
> When you have a chance, I would love to know what you are on to...
>
>
> - Scott
poster:bleauberry
thread:850347
URL: http://www.dr-bob.org/babble/20080903/msgs/850408.html