Posted by SLS on September 4, 2008, at 18:56:53
In reply to SLS and all....5ht1a autoreceptor antagonists...., posted by bleauberry on September 4, 2008, at 15:36:07
> Could you please help me construct a list of medications that are 5ht1a autoreceptor antagonists? I don't want to go into long detail about why, just know that there is very good reason for it pertaining to my treatment. I am on the hunt for one that will specifically prevent 5ht1a from being excessively sensitive so as to allow enhanced transmission.
1. pindolol - 5-HT1a somatodendritic autoreceptor antagonist; NE beta 1 receptor antagonist
> I don't know about 5ht1a agonists or partial agonists, but if you do, please share. Anything that will wake up the receptors and keep them from oversensing too much serotonin when in fact there isn't enough.
1. buspirone - 5-HT1a postsynaptic partial agonist; 5-HT1a autoreceptor full agonist; D2 receptor antagonist; NE alpha2 receptor antagonist (1-PP metabolite)2. gepirone - 5-HT1a postsynaptic partial agonist; 5-HT1a autoreceptor full agonist; NE alpha2 receptor antagonist (1-PP metabolite)
3. ipsapirone - 5-HT1a postsynaptic partial agonist; 5-HT1a autoreceptor full agonist; NE alpha2 receptor antagonist (1-PP metabolite)
4. flexinoxan - 5-HT1a postsynaptic partial agonist; 5-HT1a autoreceptor full agonist
* Repeated administration of milnacipran induces rapid desensitization of somatodendritic 5-HT1A autoreceptors but not postsynaptic 5-HT1A receptors
When you have a chance, I would love to know what you are on to...
- Scott
poster:SLS
thread:850347
URL: http://www.dr-bob.org/babble/20080903/msgs/850384.html