Posted by eric wagner on July 28, 2008, at 12:16:01
In reply to Re: Full trial of Panate w/ no response?, posted by bleauberry on July 27, 2008, at 19:12:14
> Sorry I can't help on Parnate much, other than to say give it a higher dose and longer time. I've heard people needed twice the dose you are taking, and that a good trial is in the neighborhood of 12 weeks.
>
> And I'm sorry you are in the same boat as many of us. Hopefully we can swap ideas and make some advancements.
>
> I wonder if your diagnosis is accurate? I mean, depression, sure. But from what? At this point you kind of have to question the whole deficient transmitter thing in your case. Other things cause depression besides just that. Even if you have zero bipolar symptoms, ever tried abilify, lamictal, depakote, stuff like that? Dopamine agonists? Other ADs popular everywhere else in the world except USA? Japan's premier AD is Milnacipran. I heard of someone who failed ECT and responded to Milnacipran. Tianeptine is another one. I can vouch for both of these, personal experience, as being a world different than what the FDA limits us to. And there is low dose Amisulpride. And if you did ok with the stimulants, maybe all you needed to do was add Memantine to them to revive their initial effects.
>
> Hopefully Parnate will do something with more time and a higher dose. If not, at least then you know it would probably be a good move to look at things with totally different mechanisms than the reuptake/maoi route.
>
> Anyway, long story short, fingers crossed things will go your way in the next 2 months and if they don't then look beyond the monoamine theory.I'm trialing this Parnate for the long haul, being one of the last possibilities of medications left
I was on Emsam for 3 months w/ no response whatsoever, so hopefully this MAOI will work
I feel my depression may be genetic, a result of trauma/abuse as a child, drug / alcohol use / abuse for 13 years, and / or some other possibility
All of your suggestions listed are very good ones, & thoughts I've had of trying for a while
I've already spoke to my Psychiatrist about the possibility of filling out the FDA form to use a non-approved medication, if Parnate fails to provide an acceptable response
We've tried just about everything approved by the FDA
Maybe the Daytrana/Memantine combo would be a good trial prior to a medication not approved in the US
Do you know of any posts where people have used Memantine in combination w/ a stimulant & got the response they were hoping for?
Thank you for your response, info. & very appreciated suggestions / possible routes to try
Take Care & Be Well,
Eric M. Wagner
poster:eric wagner
thread:842413
URL: http://www.dr-bob.org/babble/20080727/msgs/842581.html