Posted by bleauberry on July 27, 2008, at 19:12:14
In reply to Full trial of Panate w/ no response?, posted by eric wagner on July 27, 2008, at 17:13:17
Sorry I can't help on Parnate much, other than to say give it a higher dose and longer time. I've heard people needed twice the dose you are taking, and that a good trial is in the neighborhood of 12 weeks.
And I'm sorry you are in the same boat as many of us. Hopefully we can swap ideas and make some advancements.
I wonder if your diagnosis is accurate? I mean, depression, sure. But from what? At this point you kind of have to question the whole deficient transmitter thing in your case. Other things cause depression besides just that. Even if you have zero bipolar symptoms, ever tried abilify, lamictal, depakote, stuff like that? Dopamine agonists? Other ADs popular everywhere else in the world except USA? Japan's premier AD is Milnacipran. I heard of someone who failed ECT and responded to Milnacipran. Tianeptine is another one. I can vouch for both of these, personal experience, as being a world different than what the FDA limits us to. And there is low dose Amisulpride. And if you did ok with the stimulants, maybe all you needed to do was add Memantine to them to revive their initial effects.
Hopefully Parnate will do something with more time and a higher dose. If not, at least then you know it would probably be a good move to look at things with totally different mechanisms than the reuptake/maoi route.
Anyway, long story short, fingers crossed things will go your way in the next 2 months and if they don't then look beyond the monoamine theory.
poster:bleauberry
thread:842413
URL: http://www.dr-bob.org/babble/20080727/msgs/842440.html