Posted by Marty on July 24, 2008, at 13:59:34
In reply to Re: Agomelatine- Anyone tried it? Share your Info pls!, posted by NegCreep on July 24, 2008, at 12:35:58
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> Hi Marty....off the top of my head.....
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Hi> I havent tried melatonin, as whenever I couldnt sleep on SSRIs Id either reach for Nytol, Zoplicon or "insert downer here".
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Okay. Well, some are taking it for depression. My trial was for depression, not insomnia.> As a result Ive never really paid it that much attention untill now ive started reading about Agomelatine. I suspect that Melatonin has secondary action on other neurotransmiter recptors that could account for the depression you spoke of.
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Yes. There's more to M1 and M2 than sleep regulation / Circardian regulation.
> As for the anxiety you experienced from ingesting precursors like trytophan. I would put this down to the unselective action of natural serotonin.
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Indeed, it could be just that. Serotonin, just like dopamine, has a dichotomous nature. At least at the receptor level and their induce effects; "Serotonin = feel good" is oversimplistic and is just bad pop-science promoted by years of big pharma ADs marketting.
> Indeed, this is why many ppl experience increased anxiety when first starting on an SSRI, although this reduces after about 2 weeks when the recptors desensitise to the increased serotonin in the synapse.
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Yes, this is part of the first 2 weeks story.> Another thing to note is that selective serotonin reuptake inhibitors are called so because they are selective and only target a few types of 5HT recptors.
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I have to disagree.
Quoting Wikipedia:"SSRIs are described as 'selective' because they affect only the reuptake pumps responsible for serotonin, as opposed to earlier antidepressants, which affect other monoamine neurotransmitters as well. Because of this, SSRIs lack some of the side effects of the more general drugs."
SSRIs target every 5-HT receptors to some extent.
> This could account for improvement over precursors and older ' less selective' drugs.
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Indeed. Other receptors affinity (ie Histamine) account for TCA and other less selective drugs harsh side effects.
> So yeah now we have Agomelatine, something totally new. This drug primary acts on the M1 and M2 receptors as an agonist, helping you reset your body clock and get some sleep. I personally am not really interested in this aspect of the drug....yeah ok its cool if I sleep well but its not so much of a problem for me.
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Can't remember but is it reported has being sedative ?
> Im much more interested in the drugs secondary acion as a 5-HT2C antagonist, and 5-HT2B antagonist. Its this action which indirectly accounts for the drugs alledged antidepressant/anxiolytic effects minus all the regular side effects of antidepressants to date....Brilliant!
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And some antipsychotics also. "for the drugS" ? you mean SRIs or Agomelatine ? for Agomelatine it's fact, but for other SRIs most doesn't antagonize 5-HT2A/5-HT2B except Serzone and somehow Tianeptine which by accelerating reuptake of 5-HT reduce 5-HT2A/5-HT2B (etc) stimulation.I wonder if upregulation doesn't make those kind of ADs even more suceptible to poop-out.
> I just hope it lives up to the hype. Of the 2 reports Ive read online both were very positive, and I cant wait to give it a go. :)
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I definitively try it when it got approval. Do you have the links of those 2 reports ?
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> ps I wouldnt worry this aint no melatonin. :)
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Yeah. Writing my last reply to you helped me saw how much this rational was flawed. In fact thinking about it it may even tell the exact opposite of what I originally thought. :)
/\/\arty
poster:Marty
thread:841653
URL: http://www.dr-bob.org/babble/20080718/msgs/841802.html