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Re: Nitrous Oxide

Posted by undopaminergic on June 5, 2008, at 14:22:04

In reply to Re: Nitrous Oxide, posted by Amigan on June 5, 2008, at 11:51:51

>
> I also read somewhere that high amounts of N2O causes brain damage.
>

The so-called Olney's lesions? It seems that all substances with considerable potency as NMDA-antagonists are capable of causing this pattern of damage, at least in some species. As far as I know, Olney's lesions have still not been observed in monkeys or primates, and in this case, there is a considerable probability for differences between rodents and more advanced species, as in the latter, the brain structures implicated in Olney's lesions are very much more advanced.


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