Posted by mari stella on May 24, 2008, at 19:12:51
In reply to Re: This CAN NOT be possible!, posted by undopaminergic on May 24, 2008, at 16:53:07
Undopa,
So just because this is happening with adderall does NOT mean it will happen with ritalin type stims? Thats good news...I was prescibed focalin though and I never really noticed anything at all when I took it.
On the addfourms someone just posted regarding the info I found here (repeated elsewhere) about nmda antagonists and tolerance. I dont know the original author...Anyway this person said they believed the *nmda antagonists as tolerance reducer* was wrong. He writes
"
The observation means at most you can lower the
dose of a stimulant when used in combination with a
NMDA antagonists. Its easy to see how a person
would confuse reduce tolerance and drug potentiation.
Ultimately your likely merely taking a second stimulant.
"'I wish there was more data, I also wished I could find more personal accounts. I have read where some people used dxm and it "worked" but these were people who did not have tolerance issues like mine. They just wanted to protect themselves. IF their tolerance wasnt going up anyway than who can say if it "worked"?
I am still willing to try, and I am still hoping the original "mementine" poster might see this OR anyone who has THIS problem and has been sucesfull solving it. (Yes, I believe bulldog has this kind of idiosyncratic tolerance, but has not been able to test the mementine theory due to side effects yes?) So anyone???
I did a test dose 6 days after last dose (and had only taking it 6 days total to begin with) and found that my tolerance is still solid at 30mg. Some slight cns effects but my second 30mg dose did not kick in so all effects gone in 5 hours. Thats pretty scary. I thought I might be able to get a few days a week...I am going to give it another week and I AM going to try DXM as it is the only thing available to me. If one more week isnt enough, I will wait a month and be ordering mementine from an international source.
I suppose I can either be the person who PROVES nmda antagonists reduce (or delay) tolerance, OR I will be able to say they do not. At least for me.
Right now, I am wondering if anyone has hard facts regarding time and tolerance lowering. I think I read an abstract at pubmed that said d2 downregulation still shown at 3 days but not after 14. But Im a dunce and those abstracts are above me.
Also, I still have not decided to to tell Dr. I think not at first as official protocal is to stop stimulant therapy with adhd when compleate tolerance develops.
poster:mari stella
thread:829948
URL: http://www.dr-bob.org/babble/20080519/msgs/830957.html