Posted by SLS on May 9, 2008, at 5:00:41
In reply to Wonder Why Wellbutrin was So Bad, posted by bleauberry on May 8, 2008, at 20:27:20
Hi BB.
I always react to Wellbutrin by feeling worse. It is the depression itself that gets worse, and not some added dimension of suffering.
It would be nice to know what caused these reactions, so that you might glean a hint as to what biological pathology exists in the brain. Just to know which drugs to avoid would be nice.
Unfortunately, Wellbutrin is a poorly understood drug, and I don't think there is enough information readily available to draw conclusions. If I had to choose between DA and NE reuptake, I would choose the NE as the culprit at some point along the chain of events, and not necessarily the result of reuptake inhibition.
- Scott> Wellbutrin in 4 days took me from medium depression to suicidal ideation and almost total incapacitation. Barely able to get through work. Thought I was hiding it pretty well, but at least 5 people commented stuff like, "Smile, it aint that bad", "Don't be so depressed it's a sunny day, "You don't seem like yourself", "Are you ok?" People noticed for sure despite my years of training at hiding it.
>
> Anyway, first two days were the usual wellbutrin stuff...nervousness, heart palpitations, lousy sleep, sweating. I got through that ok. Then third day was total mind numbing calm and deep dark clouds without even a hint of any of the earlier stimulation. Weird also is that sex drive went from normal to absolute zero.
>
> If I ever wanted to feel as bad as anyone could possibly feel, all I need do is take wellbutrin. I've had periods of really really deep bad depression in my life, but it's hard to recall any as bad as what wellbutrin did.
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> I wonder what mechanism did that?
>
> Doses were only 75mg per day. Scary to think any more might have had me driving my car into a tree to end it all.
>
> It's 24 hours since the final dose so I have hope to return to my baseline within the next day, two or three. Baseline is lousy, but a whole lot better than wellbutrin. I just wonder what mechanism it was that did that. Hard to explain, but it didn't feel like a dopamine thing or a norepinephrine thing. Maybe it was, dunno.
poster:SLS
thread:828024
URL: http://www.dr-bob.org/babble/20080430/msgs/828097.html