Posted by Bob on May 8, 2008, at 21:20:12
In reply to Wonder Why Wellbutrin was So Bad, posted by bleauberry on May 8, 2008, at 20:27:20
> Wellbutrin in 4 days took me from medium depression to suicidal ideation and almost total incapacitation. Barely able to get through work. Thought I was hiding it pretty well, but at least 5 people commented stuff like, "Smile, it aint that bad", "Don't be so depressed it's a sunny day, "You don't seem like yourself", "Are you ok?" People noticed for sure despite my years of training at hiding it.
>
> Anyway, first two days were the usual wellbutrin stuff...nervousness, heart palpitations, lousy sleep, sweating. I got through that ok. Then third day was total mind numbing calm and deep dark clouds without even a hint of any of the earlier stimulation. Weird also is that sex drive went from normal to absolute zero.
>
> If I ever wanted to feel as bad as anyone could possibly feel, all I need do is take wellbutrin. I've had periods of really really deep bad depression in my life, but it's hard to recall any as bad as what wellbutrin did.
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> I wonder what mechanism did that?
>
> Doses were only 75mg per day. Scary to think any more might have had me driving my car into a tree to end it all.
>
> It's 24 hours since the final dose so I have hope to return to my baseline within the next day, two or three. Baseline is lousy, but a whole lot better than wellbutrin. I just wonder what mechanism it was that did that. Hard to explain, but it didn't feel like a dopamine thing or a norepinephrine thing. Maybe it was, dunno.I can't really tell you why what happened happened (and I suspect no one can), but I can maybe offer you a very small consolation that I've had many terrible outcomes to treatments over the years, some quite similar to what you describe where I can't make any sense of it. I've had meds that have almost killed me and it was all I could do to discontinue it without offing myself. No one can ever, ever tell me why.
In any case, I'm sorry to hear that your experience went so badly.
poster:Bob
thread:828024
URL: http://www.dr-bob.org/babble/20080430/msgs/828038.html