Posted by SLS on May 5, 2008, at 20:03:53
In reply to Re: SAMe Combined with Antidepressants. » SLS, posted by bleauberry on May 5, 2008, at 19:04:00
> I've followed all your posts, so I am well educated on the timeframe of response, pattern of response, and dosing quirks. Thanks much for all that. Very helpful.
I am glad to be of help. I just want to make you aware that I have still not established the minimum effective dosage for myself. I deteriorated after 3 days at 3.75mg. Lowering the dosage was an experiment to attempt to relieve myself of sleep disturbances. It might be an effect of combining it with Nardil. Having returned to the higher dosage, I feel much better this evening. I'm praying that this is the right move. I really didn't want to screw around too much, as I have a school exam tomorrow. In any event, it is my belief that one should start Deplin at 7.50mg. If it is tolerated, you will probably not see significant results for a month or two. I will be curious to see what your pattern of response is.
I think I mentioned that I met another patient of my doctor's who is doing remarkably well upon the addition of Deplin 7.50mg to Cymbalta and tryptophan. She never felt as well as she does now after 16 years of trying. She tolerates Deplin very well. Listen, I might go for doubling the dosage. I hate to seem so cavalier in my dosing of this drug, but I don't think there is yet enough experience with it to have a good feel for how best to use it. The kinetics demonstrated by the paper Ron Hill posted a link to provides some rationale as to why it takes 1-3 months for Deplin to become effective. It takes that long for it to reach its maximal concentration in the brain.
Good luck with Deplin. I hope it provides you with as robust an antidepressant response as it has given me. It would be helpful for you to post your experiences so that we can all learn more about the behavior of this substance.
On another note, I'm curious if you had the chance to read letter I wrote to the NJ legislature. Do you know whether this is a problem in any other state?
http://www.dr-bob.org/babble/20080430/msgs/826866.html
Thanks.
- Scott
poster:SLS
thread:827188
URL: http://www.dr-bob.org/babble/20080430/msgs/827411.html