Posted by JDx on April 23, 2008, at 5:40:29
In reply to Re: cognitive problems from solian, posted by undopaminergic on April 21, 2008, at 4:53:36
> No, the symptoms existed before Ritalin, which is one of the attempts to treat them.
>IMO ritalin is a bad choice in order to improve motivations.as far as i know high amount of dopamine activity doesn't reflect good working motivations but other aspects like rate of fire and pattern of fire of DA neurons, and ritalin doesn't help with that ( on the contrary)
> That's interesting, as my experience with risperidone was the opposite: it made me lethargic, and more apathetic and anhedonic.
>
well , I make differentiation between the serotnin antagonism mechanism which makes the depression like symptoms you described, and the DA (and NE) mechanism which has the antipsychotic effect which
fix the motivations aspects- that in my experience reflects in me having additional value to perception of things ie-when i am taking Risperdal I really have sexual desire towards women , i really enjoy watching women, curiosity to learn things, and excitments from little things; though it decreases my mood and makes me feel depressed - which makes me low energy , not happy etc..
> > It makes sens, i mean- ritalin messes with dopamine in all synapses in the brain, and not only those realated to attation, but also those which responsible for motivations
> > >
>
> Yes, but in my experience it improves motivation - at least until tolerance develops. The drug tends to lose it efficacy, necessitating "drug holidays" to restore effectiveness.
>
>
As far as i know tolerance doesn't develops with ritalin (otherwise you would need to increase ritalin dosage every few months). Mybe because it has short half-life , and DA receptors in the brain has time reAdjust at night when no ritalin in your blood..
poster:JDx
thread:823096
URL: http://www.dr-bob.org/babble/20080420/msgs/824926.html