Posted by undopaminergic on April 15, 2008, at 10:31:59
In reply to cognitive problems from solian, posted by JDx on April 13, 2008, at 17:48:41
Like you, I use methylphenidate (Ritalin, Concerta, etc.) and amisulpride (Solian), but I haven't noticed the memory impairing effect you describe.
One possibility is that amisulpride and methylphenidate potentiate each other too much in some areas of the brain. In particular, the prefrontal cortex is sensitive to excessive dopamine (and noradrenaline) levels. There is evidence that alpha2A-adrenergic agonists are effective for treating such conditions. One such drug - guanfacine - has also proven useful for normalising some cognitive abnormalities in schizotypal personality disorder (a schizophrenia-spectrum disorder). Therefore, guanfacine may be worth a try (it's also good for ADHD).
One study found memantine to be effective for negative (but not cognitive) symptoms in schizophrenia, so you may wish to look into that too.
poster:undopaminergic
thread:823096
URL: http://www.dr-bob.org/babble/20080412/msgs/823421.html