Posted by Amigan on April 3, 2008, at 16:06:01
In reply to Re: High blood pressure on Selegiline!, posted by Dopamine123 on April 3, 2008, at 15:50:56
> You could try lowering the dose. MAO-A inhibition kicks in at a higher dose of selegiline and leads to an increase in norephinephrine. At a lower dose, you are more likely to just get the MAO-B inhibition and dopamine increase.
I believe that i already receive a relatively low dose, but,
> Probably a beta blocker would be the best drug to try to prevent the increase in blood pressure due to norepinephrine.how sure are you about this? From what i have read, beta blockers can have exactly the opposite results in the present of a sympathomimetic factor and perhaps in cases of excessive NE, too.
The Beta receptors in blood vessels are responsible for vasodilation, while the Alpha receptors for vasoconstriction. THUS, if you block the B receptors, while the Alpha ones remain stimulated by the excessive N,NE or the SM factor, you have an increase in blood pressure.
poster:Amigan
thread:819397
URL: http://www.dr-bob.org/babble/20080330/msgs/821374.html