Posted by Amigan on March 23, 2008, at 16:07:57
In reply to Re: High blood pressure on Selegiline!, posted by undopaminergic on March 23, 2008, at 14:15:59
> > Hello.
> > Has anyone noticed an increase on his blood pressure while he/she is on Selegiline?
> > I do, although i'm not 100% sure that Selegiline is responsible for this, but it is the prime suspect. I only take a micro dose of Sulpiride with it, currently.
> > I take 10-15mg orally. Although, dietary restriction is not nessecary at this dosage, i do avoid tyramine-rich foods, so the rise in my BP is not tyramine related.
> > So.. I basically want to ask 2 things:
> >
> > a)Has anyone else experienced this?
>
> Transiently, at some point when starting it, I noticed such a tendency. On the other hand, many people have experienced a hypotensive effect (even more so with L-dopa).
>
> > b) what is the best medical approach to treat Selegiline-induced hypertension?
> > Ca-blockers?
> > B-blockers?
> > ACE inhibitors + a diuretic?
> > Don't suggest clonidine, please. I know that it should be effective, but it also kind-of cancels the effect of Selegiline due to the sedation it causes.
>
> The most logical agents would seem to be alpha1-adrenergic antagonists (doxazosin, prazosin, etc.)Interesting. I know about this agents. I didn't include them on the list because i thought that they are not effective for the treatment of hypertension. Mainly because i haven't yet see/hear a doctor prescribing them to a patience with high BP.
> and alpha2-adrenergic agonists (guanfacine, guanabenz). I've used guanfacine, as it has been shown to improve working memory and ADHD (those benefits are more subtle, however, than with stimulants - especially in cases complicated by other symptroms such as apathy and lack of energy).
Yes but, isn't guanfacine awfully similar to Clonidine?.. :)
poster:Amigan
thread:819397
URL: http://www.dr-bob.org/babble/20080316/msgs/819549.html