Posted by Jedi on March 5, 2008, at 21:33:53
In reply to Re: Anyone have LASTING success on Nardil??? » Jedi, posted by maoi_wowee on March 5, 2008, at 15:31:55
> Thanks, Jedi! I know what you're saying about that initial Nardil euphoria; those were probably the greatest couple of weeks of my life!
>
> Do you find that you can stay on 90mg of Nardil for extended periods of time without becoming desensitized to it and having to raise the dose? I am contemplating upping my dose from 75mg to 82.5 or 90mg, but I don't want to end up in a position where Nardil starts to poop out (even more) and I'm unable to raise the dose...
>
> thanks!I've been on 90mg of Nardil for most of the time I've used the med. Most MDs don't want to go above that. However I have taken 105mg and 120mg several times, it didn't seem to make that much difference for me. There are augmentors that can be added to Nardil, but you will usually have to have a good psychopharmacologist prescribe them. Some psychiatrists will, flat out, not prescribe a MAOI. I had one like that, he almost killed me before I found a MD who would look at my research and past history and do the logical thing.
Take care,
JediReferences:
J Clin Psychiatry. 1985 Jun;46(6):206-9.
Combined MAOI, TCA, and direct stimulant therapy of treatment-resistant depression.Feighner JP, Herbstein J, Damlouji N.
Patients with "treatment resistant" depression who do not respond to standard methods or relapse over time have a moral and legitimate right to innovative therapy. Combined treatment with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), and stimulants has been resisted by practitioners because of hypertensive and hyperthermic crises noted in certain cases. This paper reports a case series demonstrating the safety and efficacy of adding a stimulant to an MAOI or to a combination of TCA and MAOI in the treatment of intractable depression.
PMID: 3997787 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/15183599?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Treatment and response in refractory depression: results from a specialist affective disorders service.Kennedy N, Paykel ES.
Department of Psychiatry, University of Cambridge, UK. N.Kennedy@iop.kcl.ac.uk...
Patients received higher antidepressant doses and more combinations on the specialist service. Very-high-dose antidepressants (tricyclics, velafaxine or tricyclic--MAOI combinations), usually augmented with lithium and often combined with ECT, were the most effective somatic treatments. Most subjects improved substantially, but few reached premorbid levels. LIMITATIONS: The study was retrospective. Treatment courses were sequential rather than random. CONCLUSIONS: Refractory depression is responsive to vigorous somatic therapy, although most patients continue with some symptoms.
PMID: 15183599 [PubMed - indexed for MEDLINE]
poster:Jedi
thread:816254
URL: http://www.dr-bob.org/babble/20080303/msgs/816461.html