Posted by SLS on January 13, 2008, at 21:13:24
In reply to Re: Deplin is a drug, not a nutritional supplement, posted by linkadge on January 13, 2008, at 20:43:46
> > What percentage?
> I don't know, but I don't think that data is securely established for deplin either.What would you need to see before declaring Deplin something more therapeutic than folic acid?
> >My recommendation is to try Deplin first if you >prefer to enhance your chances of responding to >it as an augmentor.
> I'm not saying don't try it.
>
> I'm just saying that a number of studies have linked low serum folate to antidepressant resistance. If deplin is not an option for you, it folic acid might be worth a try.Why would Deplin not be an option? Is it prohibitively expensive or just certified not to be effective enough as to indicate that folic acid should be the first choice?
I know what I know. Deplin works for me. Folic acid does not. I am somewhat familiar with the bioavailability of L-methylfolate and its participation in methionine metabolic cycles in the brain as well as its pharmacokinetics. If you prefer more detailed explanations as to what are the differences between Deplin and folic acid, Google makes a wonderful resource to find them. Certainly, your own research will be more convincing than my words. I would suggest using Google to learn more about folic acid and L-methylfolate dynamics.
What do you think about the "methyl trap" theory?
> > I guess we'll see the clinical separation >between these two substances as clinical usage increases.
> Well thats the idea. However, the issue of patentability with undoubtedly cloud matters.
Who cares? The stuff exists. I don't care either how or why other than to secure its continued availability.
> > For what it is worth, I have tried mega-doses of >folic acid before. I experienced only >flatulence. I have tried Deplin. I am responding >much better 2 months subsequent to its >introduction. That's good enough for me to >indicate there is something special about taking >Deplin over folic acid.
>
> Perhaps. Deplin also has a name and a specific indication. Folic acid is just a $2 vitamin.Again, I would encourage you to do your own investigation. The answers to your questions are available and quite simple - even for a layman like me.
- Scott
poster:SLS
thread:806127
URL: http://www.dr-bob.org/babble/20080105/msgs/806279.html