Posted by SLS on January 13, 2008, at 12:21:13
In reply to Re: Deplin is a drug, not a nutritional supplement, posted by Jamal Spelling on January 13, 2008, at 9:36:13
> (1) What is the relationship between Deplin (L-methylfolate), L-5-methyl-tetrahydrofolate, and 5-formyl-tetrahydrofolate?
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> and
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> (2) I've seen claims that Deplin only works concomitant with prescriptions ADs. If Deplin helps synthesise neurotransmitters, why can it not work by itself?
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Hi.I don't know. Not to be a wise-guy, but if it doesn't, then it just doesn't.
I find questions like this to be esoteric and of heuristic value only. My simple answer is to just report clinical observations without trying to account for them. Scientists cannot account for them either.
For the sake of heuristics: It is possible that increasing the synthesis of presynaptic neurotransmitter is kept in check by MAO. I guess one idea of treating depression with drugs is to increase the concentration of neurotransmitter in the synaptic cleft. Apparently, this does not happen in the absence of an MAOI or reuptake inhibitor or a presynaptic receptor antagonist. L-methylfolate, thus it increases the supply of neurotransmitter, but does not stimulate its action-potential induced release.
Just a few esoteric thoughts...
My recommendation is to experiment with Deplin in combination with varioius psychotropic drugs. At the moment, clinicians don't have enough experience with Deplin in order to use it so selectively.
For the sake of increasing one's success at finding a treatment that works, I recommend that one not take too seriously their armchair psychopharmacologist ideas such that they make clinical decisions based upon them. We don't even know how lithium performs physiologically. There is an incredible array of data relating to it properties, but none has yet emerged as the singular psychotropic mechanism of action. It probably performs or affects multiple physiological processes to exert its therapeutic effects.
This post has not been conceived in an effort to identify the behaviors of anyone in particular.
I'll just continue taking my Deplin. It works for me. I don't know why.
Currently:Nardil 90mg
nortriptyline 150mg
Lamictal 200mg
Abilify 20mg
Deplin 7.5mg
- Scott
poster:SLS
thread:806127
URL: http://www.dr-bob.org/babble/20080105/msgs/806146.html