Posted by florence on December 6, 2007, at 15:42:51
In reply to Re: Here's one!, posted by Anonymoose on December 6, 2007, at 3:09:59
Thanks for more info. Not sure if I can answer your last question. Could it be similar to Remeron (mirtazapine)- in this explanation.. It is an SNRI but I could not figure out why it acted on serotonin..
"By blocking the inhibitory PREsynaptic alpha 2 adrenergic autoreceptors and stimulating only the 5HT1A receptors, it ENHANCES noradrenaline and serotonin release while also blocking 2 specific serotonin receptors: 5HT2 and 5HT3 implicated in dark moods and anxiety.
By contrast, stimulation of the 5HT2A receptors accounts for the INITIAL anxiety, insomnia and sexual dysfunction sometimes reported with the other SSRIs. Stimulation of the 5HT3 receptors causes nausea.
Unfortunately, remeron (mirtazapine) is a potent blocker of the histamine H1 receptors, too. So, it tends to have a somewhat sedative effect. This profile may be good for agitated depressives and insomniacs. Again, it is scarcely a recipe for life-affirmation."
? Increase in D2D3 receptor responsiveness may also be responsible for the clinical AD action of SSRIs.
Not sure where I got the above info...maybe on this site yrs ago.This is from biospychiatry.com Don't know if it is still around...
The Dopamine Connection
What's missing, crucially is vigorous and prolonged stimulation of meso cortico limbic dopamine function. Mesolimbic dopamine system serves as the final common pathway for pleasure in the brain. Enhanced responsiveness of POST-synaptic dopamine D2/D3 receptors is crucial to long term emotional well-being.In so far as they work, all "serotonergic" and "noradrenergic" mood brighteners eventually act on the mesolimbic dopamine pathway, albeit in differing degrees and with varying delay."
Can anyone verify this theory?
I always wondered why Provigil binds to the DA reuptake site and causes an increase in extracellular dopamine, but no increase in DA release......I don't get this..Anyway:sorry I didnt write my sources down all the time. Here's a chart showing affinities to bind to the different receptor subtypes.
Mirapex- D1 0 D2 ++ D3 +++ D2:D3 1:10
Permax- D1 + D2+++ D3 +++ D2:D3 1:1
Parlodel-- D2+++ D3 ++ D2:D3 10:1
Requip- D1 0 D2 ++ D3 +++ D2:D3 1:10Other notes I scribbled down: Mirapex and Requip can induce sleepiness (DUH)
Non-ergotoline drugs Mirapex and RequipPermax which is pergolide) and Parlodel (which is Bromocriptine) are "ergot" drugs......Nausea can occur.
I took a migraine med decades ago called Cafergot which made me vomit/diarhe for over 2 weeks. I only took one dose of 2 pills........I watched a PBS show on the Salem witches and there was a new theory that they were poisoned from ergot- a mold/fungus that grew on the rye grain......Well, guess botox and other junk can be toxic too.I invite any and all corrections to the above info-thank goodness I took notes and eventually printed info on-line.....So much has been taken off the web. florence
poster:florence
thread:797625
URL: http://www.dr-bob.org/babble/20071204/msgs/799164.html