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Tolerance to Provigil is probably only hepatic.

Posted by Astounder on November 15, 2007, at 21:07:42

In reply to Re: Provigil dependence? - Feel need 2x 200mg a da » War-Face, posted by Dinah on November 6, 2007, at 21:07:45

Provigil potently induces its own metabolism, through the CYP3A4 enzyme, and being that Provigil is extensively metabolized after being absorbed through the portal vein system, this will obviously affect its bioavailability. It also induces P-glycoprotein which Provigil is also ligand for, and this would affect its absorption.

This induction might by permanent. After 100 mg became ineffective for me after the first week, I shot up to 400 mg, which then too became useless. Even after months of staying off, neither the 100 mg dose or the 400 mg dose had any effect. This is opposite true psychostimulants which would display reverse tolerance after an extended holiday.

I've never experienced any withdrawal symptom after suddenly going off Provigil, unlike with Adderall. There was rebound fatigue and hypersomnia, sure, but it wasn't worse than before I started taking it.

It's really a shame because Provigil was the first truly anti-avoidant drug I've ever taken. Nothing else I've taken has ever touched this.


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poster:Astounder thread:793616
URL: http://www.dr-bob.org/babble/20071115/msgs/795363.html