Posted by circusboy on November 13, 2007, at 15:15:02
In reply to Re: p.s. about MAOIs » linkadge, posted by War-Face on November 6, 2007, at 15:56:38
> I found Prozac, on the other hand, to be extremely motivating (probably from NE boosting properties), although after prolonged use, it did leave me feeling dumb and forgetful and tired, in a way similar to the well-articulated cycle of SSRI use above.
>Wanted to chime in and say I've had very similar experiences with Prozac. Pretty good in the short term, then the not-insignificant cognitive deficits start to move in. Also, the Prozac-induced anxiety (5-HT2C agonism? I can't remember which receptor subtype) starts to overwhelm the positive effects as well, and I become a nervous idiot in social situations.
I was prescribed methylphenidate to help with the concentration issues, but it took a very high dose (40 - 60 mg/day) which left me in irritable withdrawal every night. Once the Prozac was out of my system, I could have a very productive day on only 10 mg methylphenidate.
As a sort of aside... I know most of us believe this here, but it's worth repeating: the secondary affinities of "selective" drugs like the SSRIs are highly significant. Prozac at the NE transporter, Zoloft at the DA transporter, (Strattera at the kappa opiate receptor...not a SSRI, but still), Lexapro doing...something sleepy... all of these things are /supposed/ to be clinically insignificant, but those of us who have tried these drugs know they're not.
poster:circusboy
thread:793535
URL: http://www.dr-bob.org/babble/20071104/msgs/794870.html