Posted by sdb on October 22, 2007, at 0:31:38
In reply to Re: Has somebody ever taken prazepam (Centrax)?, posted by amigan on October 20, 2007, at 21:45:53
> I haven't tried many benzos, but from the ones that i have tried, prazepam was the weakest...
> Now, i read in this thread that it has an extremely long onset. I wasn't informed about that when i was taking it. You think that this is why i considered it weak? Because i was expecting it to act in 1-2 hours? Perhaps..
>prazepam is not a weak benzo but the pills are in a low dosage. Librium is not a weak benzo too you could easily produce 50mg librium pills instead of 25mg librium pills.
prazepam won't kick in immediately or give you instant relieve compared to a benzo like xanax.
It can last some days until the effect is there.
prazepam has a slow resorption, the max. concentration of the metabolites will be in approx. 2-3 hours. prazepam has slight antidepressant action (who knows why?).warm regards
sdb
Compared efficacy of prazepam and clomipramine in major depression with anxiety: a multicenter controlled study.
Lemoine P, Boulenger JP, Caillard V, Tanne N, Bonnet D.Unité Clinique de Psychiatrie Biologique, C.H.S. Le Vinatier, Lyon Bron, France.
The efficacy of antidepressants is well established in major depressions, especially those with melancholic features. However, some anxiolytics also appear to have antidepressant properties at least for outpatients. 118 outpatients (25 males, 93 females, age: 18-60) with major depression according to DSM-III criteria, neither melancholic nor suicidal, reaching at least 27 on Montgomery and Asberg depression rating scale (MADRS) and 19 on Hamilton anxiety rating scale (HARS) accepted to participate this double blind study carried out by 15 G.P.s coordinated by 3 psychiatrists. After a one week placebo wash-out-single-blind period, they were randomly, double blind, assigned to one of the two following groups: PR treated with prazepam (30-60 mg), a benzodiazepine anxiolytic or CL treated clomipramine, an imipramine antidepressant (75-150 mg). Patients were evaluated at days 0, 7, 14, and 28, using MADRS, HARS, Clinical Global Impression and Hopkins symptoms check list 58. In addition, G.P.s had to meet monthly for a case discussion group. Results: groups were comparable at day 0. A highly significant improvement of MADRS and HARS scores (p less than 0.001) was observed in the total population. For the completer population evolution was also significantly positive in all the parameters studied but, considering MADRS and HSCL scores, a difference in favor of CL is observed.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID: 1775523 [PubMed - indexed for MEDLINE]
poster:sdb
thread:493236
URL: http://www.dr-bob.org/babble/20071019/msgs/790590.html