Posted by Bob on October 8, 2007, at 23:54:32
In reply to Glutamate receptor type/suicidal induction?, posted by Larry Hoover on October 8, 2007, at 17:39:36
> I haven't read the full-text yet, but this discovery might prove useful for screening depressives for this adverse effect of citalopram, or perhaps, other antidepressants.
>
> Full-text:
> http://ajp.psychiatryonline.org/cgi/content/full/164/10/1530
>
> Abstract:
> Am J Psychiatry. 2007 Oct;164(10):1530-8.
> Genetic markers of suicidal ideation emerging during citalopram treatment of major depression.
> Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ.
> Genetic Basis of Mood and Anxiety Disorders, NIMH, 35 Convent Dr., Rm. 1A207, Bethesda, MD 20892-3719. gonzalo.laje@nih.gov.
>
> OBJECTIVE: Suicidal ideation is an uncommon symptom than can emerge during antidepressant treatment. The biological basis of treatment-emergent suicidal ideation is unknown. Genetic markers may shed light on the causes of treatment-emergent suicidal ideation and help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, or specialty care. METHOD: A clinically representative cohort of outpatients with major depressive disorder who enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were treated with citalopram under a standard protocol for up to 14 weeks. DNA samples from 1,915 participants were genotyped for 768 single-nucleotide polymorphisms in 68 candidate genes. Allele and genotype frequencies were compared between the 120 participants who developed treatment-emergent suicidal ideation and those who did not. RESULTS: Two markers were significantly associated with treatment-emergent suicidal ideation in this sample (marker rs4825476, p=0.0000784, odds ratio=1.94; permutation p=0.01; marker rs2518224, p=0.0000243, odds ratio=8.23; permutation p=0.003). These markers reside within the genes GRIA3 and GRIK2, respectively, both of which encode ionotropic glutamate receptors. CONCLUSIONS: Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy. If replicated, these findings may shed light on the biological basis of this potentially dangerous adverse event and help identify patients at increased risk.
>
>
> LarI don't understand what the suicidal ideation had to do with glutamate receptors.
poster:Bob
thread:787922
URL: http://www.dr-bob.org/babble/20070929/msgs/788014.html