Posted by Meagan on September 14, 2007, at 8:37:24
In reply to Re: Why go on ENSAM if there is dietary restrict?, posted by cumulative on September 13, 2007, at 18:45:37
Thanks for your help. I have searched the threads but yours was the first that explained the equivalency of dosing between oral selegiline and the patch.
Most of the threads were from 2006, a few from 2007, but none I saw really discussing the diet and when/if it was a concern at higher doses of the transdermal.
Meagan
> Transdermal and sublingual selegiline result in much higher blood concentrations that oral dosing, primarily because first-pass metabolism (which also results in more l-amph/l-methamphetamine metabolites) is avoided.
>
> Roughly, 6 mg of the patch is reported to correspond to 20mg orally, 9mg to 30, 12mg to 40.
>
> I don't have a problem with dietary restrictions myself but there are some reports here that despite early FDA restrictions that the diet may not even be relevant for the higher patch dosages. There's a lot of threads here on EMSAM, might be worth doing a search.
>
> Good luck.
poster:Meagan
thread:782706
URL: http://www.dr-bob.org/babble/20070911/msgs/782822.html