Posted by hgi698 on July 12, 2007, at 12:04:54
In reply to Re: Is prozac causing me to blunt , or not speak, posted by Phillipa on July 6, 2007, at 12:09:03
Having too much serotonin leads to increased stimulation of two specific types of serotonin receptors (5-ht2a and 5-ht2c). Stimulation of either of these receptors leads to a reduction of dopamine in the prefrontal cortex (area of the brain right behind your forehead). The reduced dopamine in the prefrontal cortex leads to inadequate stimulation of the D1 receptor. Proper stimulation of this receptor is necessary for working memory, verbal fluency, attention, motivation and interest. Because of this, SSRI's can induce a state which is very similar to negative schizophrenia. Symptoms can include apathy, poor motivation, problems talking fluently, poor working memory and emotional blunting.
If you want to improve your condition you could possibly decrease the dose of the prozac, or you could try remeron which blocks both the 5-ht2a and 5-ht2c receptors. Or you could take a dopaminergic like wellbutrin, adderall, ritalin etc.
poster:hgi698
thread:767952
URL: http://www.dr-bob.org/babble/20070710/msgs/769168.html