Posted by yxibow on March 19, 2007, at 1:55:54
In reply to Yxibow,,,thoughts on other meds, posted by stargazer on March 18, 2007, at 23:54:33
> yxibow,
>
> really? I thought dopamine was the thing I needed and wasn't get with most of the AD's I've tried.
>
> The only meds that have done something are are Nardil, Marplan and Celexa/Wellbutrin/Adderall combo.
>
> What do these target and what other meds may hit the same targets.
>
> I'm in line to retry Nardil although the formulation change in 2003 has me worried it might not work as others have claimed.
>
> A retrial of Marplan(reformulation)in 2006 failed since Marplan was discontinued in 1994 while working very well for me. I went down hill and never had very good responses to all the SSRI's which had been released at the same time and was one reason Roche terminated its production. I later heard many successful Marplan users went on to relapse after being forced to stop it.
>
> Any thoughts on what I should try other than Nardil? I'm now on Emsam and Provigil didn't help when added. Thanks. I'm rather desparate after so many med failures and job losses becasue of recurrent depression.
>
> Stargazer
I wish I could help you on those other medications -- there are a number of people on here who are on Emsam or who have tried. I'm not by any means any expert on MAOIs. My vegetarian diet would implode my brain if I took one so I can't comment on any of it. But there are people here who have used a variety of MAOIs. It would be nice if RIMAs were available in the US, the diet issue would be somewhat less.
The dopamine issue with Zoloft is mild, it is a minor dopamine inhibitor like a neuroleptic but EPS is rare and TD is still rarer -- still I believe more SSRI cases occur on Zoloft. But we are talking lower than neuroleptic issues.
Celexa and most SSRIs prevent the reuptake of serotonin at various subreceptors, the chemistry of which is beyond me, I have wanted to study Stahl et alia. This is different from the blockade of serotonin which occurs on neuroleptics and Remeron, among other auxiliary agents that I know do that.
Wellbutrin generally raises the level of dopamine in the brain period, it could be called a SDNI, as noted by wikipedia it is a "selective catecholamine (dopamine and norepinephrine) reuptake inhibitor".
Adderall is d-amphetamine, similar but not exactly methamphetamine. Working differently from Wellbutrin it still blockades the same neurotransmitters but I can only imagine it is more intense. I have only used Wellbutrin for a period of time.
poster:yxibow
thread:741810
URL: http://www.dr-bob.org/babble/20070314/msgs/742065.html