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Re: Why Most New Antidepressants Are Ineffective

Posted by Brutus1 on February 20, 2007, at 14:24:17

In reply to Re: Why Most New Antidepressants Are Ineffective, posted by bulldog2 on February 20, 2007, at 12:03:28

So where does an atypical SSRI fit in this discussion?

"In a study comparing the effects of fluoxetine, paroxetine, sertraline, citalopram, and fluvoxamine on extracellular concentrations of serotonin, dopamine, and norepinepherine in the prefrontal cortex, only fluoxetine showed robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration,[13] suggesting that fluoxetine is an atypical SSRI"

Personally I have never tried it, but I'll bet most posters on this board have. (And please, I'm not advocating SSRI's TCA's, MAOI's etc. We are all wired differently with numerous root causes and numerous levels of comorbidity.)

It's been around 20 plus years. There has to some meta data to support it's efficiency one way or another (or most likely both :))

B



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poster:Brutus1 thread:733613
URL: http://www.dr-bob.org/babble/20070219/msgs/734475.html