Posted by psychobot5000 on January 21, 2007, at 20:30:10
In reply to Re: Is paroxetine more dual action than venlafaxine ?, posted by linkadge on January 20, 2007, at 19:00:29
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> Paxil kindof felt like a TCA. It also made me feel a little bit psychotic which none of the other SSRI's did.
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> LinkadgeAccording to various things I've read, Paxil is (according to metaanalyses) very slightly more effective than other SSRIs (at least before Celexa). It also has higher anticholinergic effects, and maybe H1 blocking too, which are believed to account for some of its sedation.
I saw one chart about a year ago, with various binding affinities of tricyclics and SSRIs and what-nots, and had to keep checking back and forth in confusion, because Paroxetine was clearly listed there with a modestly -higher- noradrenaline reuptake inhibition than Effexor. I had always been told effexor was fairly weak on NA, but really! Weaker than a conventional SSRI? How do they get off calling it an SNRI then?
In any case, the picture I get from Paxil is: 5-ht reuptake inbition, modest NA reuptake inhibition, and receptor effects on ACH and possibly H1. Sounds a hell of a lot like a tricyclic to me!
But I can't help but think we're missing something, if Effexor/Venlafaxine has gotten away with claiming to be an SNRI for all this time...
poster:psychobot5000
thread:724101
URL: http://www.dr-bob.org/babble/20070119/msgs/724980.html