Posted by Larry Hoover on January 20, 2007, at 13:24:53
In reply to Is paroxetine more dual action than venlafaxine ?, posted by linkadge on January 19, 2007, at 15:31:07
> http://jpet.aspetjournals.org/cgi/content/full/283/3/1305
>
> "Of particular interest were the findings that paroxetine, generally thought of as a selective SERT antagonist, possesses moderately high affinity for the NET and that venlafaxine, which has been described as a "dual uptake inhibitor", possesses weak affinity for the NET"
>
>
> LinkadgeThe Ki (concentration units) of paroxetine binding affinity to the norepinephrine transporter is about one-tenth that of venlafaxine, i.e. equal inhibition of the transporter at one-tenth the concentration. Yes, the paper you cite is correct.
Lar
poster:Larry Hoover
thread:724101
URL: http://www.dr-bob.org/babble/20070119/msgs/724457.html